On Friday the 29th of April, 2011, England’s Prince William will marry the graceful and poised Miss Catherine Middleton in London’s hallowed Westminster Abbey. As the world tunes in to watch the “wedding of the century,” Cell Culture explores the more biological aspects of this historic union, including the neurocircuits that strengthen a marriage, the epigenetic changes that transform a “commoner” into a queen, and the search process for finding a high-affinity partner in a sea of weak interactions.